Isaac married Martha POWERS on 10 Jan 1844 in New Hanover, North Carolina, USA. Martha (daughter of Kinchen POWERS and Tobitha NEW) was born about 1810 in New Hanover County, North Carolina; died before 1855 in New Hanover County, North Carolina. [Group Sheet]

1. Mary Eliza WEST was born in 1845 in Duplin Co, NC; and died.
2. Kinchen Daniel WEST was born on 4 Jul 1846 in Wallace, N.C.; died on 27 Nov 1922 in Wallace, Duplin, North Carolina.
3. John Ephraim WEST was born on 5 May 1849 in Duplin Co, NC; died on 24 Mar 1908 in Duplin County, North Carolina, USA; was buried in Wallace, Duplin County, North Carolina, United States of America.
4. J. Milissa WEST and died.